Detalles del Título
Detalles del Título

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Título Approaches to the conformational analysis of biopharmaceuticalsLibros / Impreso - Libros
Autor(es) Lundblad, Roger L. (Autor)
Publicación Boca Raton, Florida : Chapman & Hall/CRC, ©2010
Descripción Física xiii, 354 páginas : ilustraciones ; 24 cm.
Idioma Inglés;
Series Protein Science Series
ISBN 1439807809
Clasificación(es) 615.7
QUIMICA
Materia(s) Biofarmacia; Proteínas - Conformación; Proteínas - Análisis;
Nota(s) Incluye referencias bibliográficas e índice.
CONTENIDO: Introduction to biopharmaceutical conformational analysis : issues and methods -- Comparability of biotechnological/biological products and biological generic -- Application of native electrophoresis for the study of protein conformation -- Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation -- Size-exclusion chromatography and biomolecular conformation -- Use of analytical ultracentrifugation to study biomolecular conformation -- Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules -- Light scattering and biomacromolecular conformation -- Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products -- Near-infrared spectroscopy and macromolecular conformation -- Use of mid-infrared and Fourier transform infrared spectroscopy to study conformation of biomacromolecules -- Use of Raman spectroscopy to evaluate biopharmaceutical conformation -- Use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products -- Use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation -- Use of nuclear magnetic resonance for the characterization of biotherapeutic products -- Use of chemical probes for the study of protein conformation -- Use of hydrogen exchange in the study of biopharmaceutical conformation -- Use of chemical modification for the conformational analysis of biopharmaceuticals -- Use of immunology to characterize biopharmaceutical conformation -- Use of limited proteolysis to study the conformation of proteins of biotechnological interest -- Other technologies for the characterization of conformational change in biopharmaceuticals -- Development of an experimental approach for the study of the conformation of a biological therapeutic product.
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