Incluye referencias bibliográficas e índice. CONTENIDO: Introduction to pharmacokinetics -- Review of mathematical fundamentals -- Drug pharmacokinetics following a single IV bolus administration: Drug distribution -- Drug pharmacokinetics following a single IV bolus administration: Drug clearance -- Drug pharmacokinetics following a single IV bolus administration: The rate of drug elimination -- Drug absorption following extravascular administration: Biological, physiological, and pathological considerations -- Drug absorption following extravascular administration: Molecular and physicochemical considerations -- Drug absorption following extravascular administration: Formulation factors -- Drug pharmacokinetics following single oral drug administration: rate of drug absorption -- Drug pharmacokinetics following single oral drug administration: The extent of drug absorption -- Bioequivalence -- Drug pharmacokinetics during constant rate IV infusión: The steady-state principle -- Steady-state during multiple drug administration -- Renal drug excretion -- Metabolite pharmacokinetics --Nonlinear pharmacokinetics -- Multicompartment pharmacokinetic models -- Drug pharmacokinetics following administration by intermittent intravenous infusion -- Pharmacokinetic-pharmacodynamic modeling -- Noncompartmental approach in pharmacokinetic data analysis -- Physiological approach to hepatic clearance -- Physiologically based pharmacokinetic models -- Therapeutic drug monitoring -- Pharmacokinetics in special patient populations -- Pharmacokinetic drug-drug interactions -- Pharmacogenetics: The genetic basis of pharmacokinetic and pharmacodynamic variability -- Applications of computers in pharmacokinetics -- The companion CD -- Solutions for the practice problems.
