Detalles del Título
Detalles del Título

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Título Designing multi-target drugsLibros / Impreso - Libros
Autor(es) Morphy, Richard J. (Editor)
Harris, C. John (Editor)
Publicación Cambridge, United Kingdom : RSC Publishing, ©2012
Descripción Física xxvii, 365 páginas : ilustraciones ; 24 cm.
Idioma Inglés;
Series RSC Drug discovery series (21)
ISBN 1849733627
Clasificación(es) 615.19
QUIMICA
Materia(s) Medicamentos; Drogas - Guías; Drogas - Diseño; Medicamentos - Guías;
Nota(s) Incluye referencias bibliográficas e índice.
CONTENIDO: Simple Drugs Do Not Cure Complex Diseases: The Need for Multi-Targeted Drugs -- Clinical Need and Rationale for Multi-Target Drugs in Psychiatry -- Drug Molecules and Biology: Network and Systems Aspects -- Chemoinformatic Approaches to Target Identification -- Designing Multi-Target Drugs: In Vitro Panel Screening - Biological Fingerprinting -- Phenotypic and In Vivo Screening: Lead Discovery and Drug Repurposing -- Target/s Identification Approaches - Experimental Biological Approaches -- Historical Strategies for Lead Generation -- In Silico Lead Generation Approaches in Multi-Target Drug Discovery -- The Challenges of Multi-Target Lead Optimization -- Combination Agents Versus Multi-Targeted Agents - Pros and Cons -- The Discovery of Lapatinib -- Identification and Optimization of Dual PI3K/mTOR Inhibitors -- Discovery of HDAC-Inhibiting Multi-Target Inhibitors -- Targeting Protein-Protein Interactions: Dual Inhibitors of Bcl-2 and Bcl-Xl -- Discovery of the Anti-Psychotic Drug, Ziprasidone -- The Rational Design of Triple Reuptake Inhibitors for the Treatment of Depression -- Discovery of Multi-Target Agents for Neurological Diseases via Ligand Design -- Designing Drugs with Dual Activity: Novel Dual Angiotensin II and Endothelin Receptor Antagonists -- Ethyl Urea Inhibitors of the Bacterial Type II Topoisomerases DNA Gyrase (GyrB) and Topoisomerase IV (ParE).
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113018Biblioteca Universidad Icesi2615.19/D457dDisponibleCol. General