Incluye referencias bibliográficas e índice. CONTENIDO: Atom economy: A challenge for enhanced synthetic efficiency -- Evaluating the greenness of synthesis -- Alternative feedstocks for synthesis -- Synthesis in green solvents -- Development and application of isocyanide-based multicomponent reactions -- Flow syntheses -- Synthesis without protecting groups -- Biological synthesis of pharmaceuticals -- Syntheses via C-H bond functionalizations -- Synthesis without metals -- Chemistry beyond functional group transformation -- Synthesis assisted by electricity -- Parameterization and tracking of optimization of synthesis strategy using computer spreadsheet algorithms.