Incluye referencias bibliográficas e índice. CONTENIDO: The design of safer chemicals: Past, present, and future perspectives -- Differential toxicity characterization of green alternative chemicals -- Understanding mechanisms of metabolic transformations as a tool for designing safer chemicals -- Structural and toxic mechanism-based approaches to designing safer chemicals -- Informing substitution to safer alternatives -- Design of safer chemicals - Ionic liquids -- Designing safer organocatalysts - What lessons can be learned when the rebirth of an old research area coincides with the advent of green chemistry? -- Life-cycle concepts for sustainable use of engineered nanomaterials in nanoproducts -- Drugs -- Greener chelating agents -- Improvements to the environmental performance of synthetic-based drilling muds -- Biochemical pesticides: Green chemistry designs by nature -- Property-based approaches to design rules for reduced toxicity -- Reducing carcinogenicity and mutagenicity through mechanism-based molecular design of chemicals -- Reducing ecotoxicity -- Designing for non-persistence -- Reducing physical hazards: Encouraging inherently safer production -- Interaction of chemicals with the endocrine system.