Detalles del Título
Detalles del Título

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Título Drug design: structure - and ligand - based approachesLibros / Impreso - Libros
Autor(es) Merz, Kenneth M. (Editor)
Ringe, Dagmar (Editor)
Reynolds, Charles H. (Editor)
Publicación New York, NY : Cambridge University Press, ©2010
Descripción Física x, 274 páginas : ilustraciones ; 29 cm.
Idioma Inglés;
ISBN 9780521887236
Clasificación(es) 615.19
QUIMICA
Materia(s) Drogas - Diseño; Medicamentos; Química farmacéutica; Ligandos (Bioquímica);
Nota(s) Incluye referencias bibliográficas e índice.
CONTENIDO: Progress and issues for computationally guided lead discovery and optimization / William L. Jorgensen -- Structural biology -- X-ray crystallography in the service of structure-based drug design / Dagmar Ringe -- Fragment-based structure-guided drug discovery: strategy, process, and lessons from human protein kinases / Siegfried Reich -- NMR in fragment-based drug discovery / Jonathan M. Moore -- Computational chemistry methodology -- Free-energy calculations in structure-based drug design / Scott P. Brown -- Studies of drug resistance and the dynamic behavior of HIV-1 protease through molecular dynamics simulations / Carlos Simmerling -- Docking: a domesday report / Martha S. Head -- The role of quantum mechanics in structure-based drug design / Kenneth M. Merz, Jr. -- Pharmacophore methods / Steven L. Dixon -- QSAR in drug discovery / Alexander Tropsha -- Predicting ADME properties in drug discovery / William J. Egan -- Applications to drug discovery -- Computer-aided drug design: a practical guide to protein-structure-based modeling / Charles H. Reynolds -- Structure-based drug design case study: p38 / Arthur M. Doweyko -- Structure-based design of novel P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease / Nigel J. Liverton -- Purine nucleoside phosphorylases as targets for transition-state analog design / Vern L. Schramm -- GPCR 3D modeling / Frank U. Axe -- Structure-based design of potent glycogen phosphorylase inhibitors / Qiaolin Deng.
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116638Biblioteca Universidad Icesi2615.19/D794dDisponibleCol. General